Confirming the news to the Official Club Website, Town boss Roy Keane said: "Carlos came off with a hamstring problem and he's highly unlikely to be fit, certainly to start on Saturday anyway.
"We have to be careful with him. We have pushed him a bit since he joined us. He did a lot of travelling with internationals and playing two games in a few days and then he came back and played at Middlesbrough and then again on Tuesday night.
"Liam has a swelling over his eye and we will have to look at him today and see how he is but he's doubtful as well.
"Gareth [McAuley] is obviously out as well with suspension but we have to deal with it. We have Tommy Smith and Pim available and one of those lads will get an opportunity."
In addition to Rosenior and Edwards being ruled out through injury and McAuley suspended, Town will be without Davis Norris and Luciano Civelli who are both stepping up their recovery from more long term injuries.
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