Speaking to the Official Club Website, Keane said: "Both David and Daryl have not played a lot of football this season so we have to be careful with them.
"We gave David an hour on Saturday and Murph played 80 minutes but we will have to gauge it. We will have to be very careful with Jon as well. He's an important player for us but two games in three days is a big ask.
"I have to be fair to the other lads as well. The likes of Pablo and Quinner have been training really well over the last couple of weeks and we may make one or two changes."