Jay Tabb's ankle injury rules him out, while the game is likely to come too soon for Andy Griffin and Julian Kelly, who have both had hamstring problems.
Ipswich boss Roy Keane could hand Jaime Peters a starting place.
Peters came off the bench to score a second-half equaliser in Saturday's 1-1 draw against Scunthorpe.
MATCH PREVIEW
Ipswich have started the season well, yet continue to start matches poorly. Boss Roy Keane was baffled by what he called a "shocking" first-half performance on Saturday at Scunthorpe, where Jaime Peters' second-half equaliser secured a point for Town.
Keane's side are still yet to score in the first half of a Championship match this term and their earliest goal was scored in the 50th minute. Not that Ipswich fans have too much to grumble about, with their team fourth and only one point behind second-placed Cardiff.
Reading will go above the Suffolk club on goal difference if they beat them on Tuesday night. The Royals, who are seventh, beat Barnsley on Saturday with three goals in the last 12 minutes after being reduced to 10 men when Zurab Khizanishvili was sent off.
Boss Brian McDermott felt that harsh dismissal galvanised his team, and he will be hoping that they can continue their impressive scoring record at home. Reading have scored three goals in three consecutive matches at the Madejski Stadium, winning the last two of them 3-0.
MATCH FACTS
Head-to-head
• Ipswich have won three and drawn one of their last four matches against Reading
• There has never been a goalless draw between these clubs.
Reading
• Reading are vying for a fourth win in six league games.
• Their two goals in injury time on Saturday mean they have now scored five goals in the final five minutes of Championship matches this season - more than any other team.
• They are one of three clubs in the division yet to concede in the final 15 minutes.
• Reading have won 11 of their last 15 home league games.
• The Royals have won fewer corners than any other side in Championship contests (70).
• They have had more fouls committed against them than any other club in the second tier (111).
• If selected, Matt Mills will be making his 150th career start.
Ipswich
• Ipswich have lost only one of their 11 matches this season, and are unbeaten away from home.
• Their total of 15 points after the first eight games is the Tractor Boys' best return for six years.
• Victory would leave them one shy of their total of away league wins for the whole of last season.
• A goal for Ipswich would be the club's 800th away in the second tier.
• Town have had fewer fouls committed against them than any other club in the division (59).
Source: BBC Sport