A place in next season's Football League is at stake in the game which kicks off at 4pm, Cambridge having reached the final after beating Stevenage 4-3 after both legs of their play-off semi final a fortnight ago.
Reason will be hoping to put a good performance in the match, as his contract at Town expires at the end of the season, with the Southend born player expected to hear if he will be offered a new deal early next week.
Since joining Cambridge on loan at the start of the year, Reason has appeared in seventeen games for Cambridge, scoring two goals, both of which coming in the Blue Square Premier.
You can follow all the action live from Wembley, by clicking the 'Live Scores' link at the top of the page.
Click here for a player profile on Jai Reason or click here for a game by game rundown of his season to date.