With just three games to go, and Town being 5 points ahead of seventh placed Millwall, a win on Saturday could seal the club a play-off place, while a defeat could leave a number of clubs snapping at their heals.
Speaking to the Official Club Website, Town boss Joe Royle said: "Forest will come here on Saturday and will fight for their lives because they are not out of the relegation picture yet.
"They are a decent side, better than their position suggests and I see the game as absolutely massive for us, the biggest of the season.
"We have got ourselves into a good position but we are certainly not there yet. Forest won't be easy, Sheffield United are fighting for the Play-Offs like ourselves and then Cardiff will come here relaxed on the final day and that makes them dangerous opposition.
"We have lost three games before - not so long ago actually - and that is why the Forest match is crucial for us. We must keep the momentum going that we have built up."