Wickham, 17, has missed the last three league games with a thigh strain and the Premier League target will continue to sit out.
Captain Gareth McAuley is out until at least the New Year after Achilles surgery as Roy Keane`s side look to end a miserable run of five straight defeats at Deepdale.
Young midfielder Luke Hyam is also still absent with his hamstring injury but left-back Mark Kennedy could return from his hamstring problem.
On-loan Celtic defender Darren O`Dea should be fit after picking up a knock in the defeat to Swansea last weekend while midfielder David Norris is also fit after a hamstring problem.
Source: PA
Source: PA